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Larazotide acetate

Cat. No. M10370
Larazotide acetate Structure
Synonym:

AT-1001

Size Price Availability Quantity
1mg USD 45  USD45 In stock
5mg USD 90  USD90 In stock
10mg USD 140  USD140 In stock
25mg USD 280  USD280 In stock
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Quality Control & Documentation
Biological Activity

Larazotide acetate also known as AT-1001, is a tight junction regulator and reverses leaky junctions to their normally closed state.

Chemical Information
Molecular Weight 785.89
Formula C34H59N9O12
CAS Number 881851-50-9
Solubility (25°C) Water 15 mg/mL
DMSO 2 mg/mL
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shahryar Khaleghi, et al. Therap Adv Gastroenterol. The potential utility of tight junction regulation in celiac disease: focus on larazotide acetate

[2] Shobha Gopalakrishnan, et al. Peptides. Larazotide acetate regulates epithelial tight junctions in vitro and in vivo

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Keywords: Larazotide acetate, AT-1001 supplier, Peptides, inhibitors, activators


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