Lamalbid is a natural product that can be found in Lantana montevidensis. Lamalbid inhibits ROS generation.
| Molecular Weight | 422.38 |
| Formula | C17H26O12 |
| CAS Number | 52212-87-0 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related ROS Kinase Products |
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| Pinealon
Pinealon is a 3-amino acid peptide and shows neuroprotective properties. |
| Zidesamtinib
Zidesamtinib is a potent, selective, orally active and blood-brain barrier permeable inhibitor of multiple ROS1 fusion and resistance mutations, with IC50 values of 0.7 and 7.9 nM for wild-type ROS1 and ROS1 G2032R, respectively, and does not inhibit TRK.May be useful in studies related to non-small cell lung cancer and other solid tumors. |
| GGTI-2417
GGTI-2417 is a potent and selective inhibitor of GGTase I. |
| Methyl 12-methyltridecanoate
Methyl 12-methyltridecanoate ((R)-betaxolol hydrochloride) is a biosurfactant extracted from Brevibacterium casei LS14. |
| Capsanthin
Capsanthin is a carotenoid that has been found in C. annuum. Capsanthin has antioxidant, antitumor and anti-inflammatory effects. |
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