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L-Threonine

Cat. No. M10212
L-Threonine Structure
Size Price Availability Quantity
5g USD 30  USD30 In stock
25g USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

L-threonine could adjust the balance of amino acid in feed, promote growth, improve meat quality and improve ncrease the value of feed raw materials of lower amino acid digestibility and produce the low protein feed, save protein resources, reduce the cost of feed ingredients, reduce the nitrogen content of manure and urine and decrease the concentration and release rate of animal building ammonia.

Chemical Information
Molecular Weight 119.12
Formula C4H9NO3
CAS Number 72-19-5
Solubility (25°C) Water 50 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chenxi Wang, et al. Food Funct. L-Threonine upregulates the expression of β-defensins by activating the NF-κB signaling pathway and suppressing SIRT1 expression in porcine intestinal epithelial cells

[2] Shan Wang, et al. Appl Microbiol Biotechnol. Peculiarities of promiscuous L-threonine transaldolases for enantioselective synthesis of β-hydroxy-α-amino acids

[3] Shuaiwen Wang, et al. Microb Cell Fact. Improving L-threonine production in Escherichia coli by elimination of transporters ProP and ProVWX

[4] Prasanth Kumar, et al. ACS Chem Biol. l-Threonine Transaldolase Activity Is Enabled by a Persistent Catalytic Intermediate

[5] Lei Zhao, et al. Biotechnol Appl Biochem. Transcriptomic analysis of an l-threonine-producing Escherichia coli TWF001

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