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L-Phenylalanyl-L-leucine

Cat. No. M21608
L-Phenylalanyl-L-leucine Structure
Synonym:

H-Phe-Leu-OH

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250mg USD 35  USD35 In stock
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Biological Activity

L-Phenylalanyl-L-leucine is a leucine derivative.

Chemical Information
Molecular Weight 278.35
Formula C15H22N2O3
CAS Number 3303-55-7
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Anders Broberg, et al. Amino Acids. In-peptide amino acid racemization via inter-residue oxazoline intermediates during acidic hydrolysis

[2] E Kessler, et al. Infect Immun. In vitro inhibition of Pseudomonas aeruginosa elastase by metal-chelating peptide derivatives

[3] A Spierer, et al. Curr Eye Res. The effect of 2-mercaptoacetyl-L-phenylalanyl-L-leucine, a specific inhibitor of Pseudomonas aeruginosa elastase, on experimental Pseudomonas keratitis in rabbit eyes

[4] S Blumberg, et al. Eur J Biochem. Inhibition of metalloendopeptidases by 2-mercaptoacetyl-dipeptides

[5] Filippova IYu, et al. Anal Biochem. L-Pyroglutamyl-L-phenylalanyl-L-leucine-p-nitroanilide--a chromogenic substrate for thiol proteinase assay

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Keywords: L-Phenylalanyl-L-leucine, H-Phe-Leu-OH supplier, inhibitors, activators

 
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