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L-Moses

Cat. No. M13823
L-Moses Structure
Synonym:

L-45

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Biological Activity

L-Moses (L-45) is the first potent, selective, and cell-active p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor with a Kd of 126 nM.

Chemical Information
Molecular Weight 360.46
CAS Number 2079885-05-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jocelyne Hanquier, et al. Exp Parasitol. Evaluating the GCN5b bromodomain as a novel therapeutic target against the parasite Toxoplasma gondii

[2] Moses Moustakim, et al. Angew Chem Int Ed Engl. Discovery of a PCAF Bromodomain Chemical Probe

[3] Joseph S Fernandez-Moure, et al. Int J Surg Case Rep. An unusual presentation of congenital intestinal malrotation in a nonagenarian

[4] Gary H Lyman, et al. J Clin Oncol. Biomarker Tests for Molecularly Targeted Therapies: Laying the Foundation and Fulfilling the Dream

[5] R W Holley, et al. Ciba Found Symp. A growth regulatory factor that can both inhibit and stimulate growth

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  Catalog
Abmole Inhibitor Catalog




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