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L-Cystine

Cat. No. M10521
L-Cystine Structure
Size Price Availability Quantity
500mg USD 50  USD50 In stock
1g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

L-Cystine is a non-essential amino acid for human development. L-Cystine is formed by the dimerization of two cysteines through the sulfur.

Chemical Information
Molecular Weight 240.3
Formula C6H12N2O4S2
CAS Number 56-89-3
Solubility (25°C) 1 M HCl 100 mg/mL
Storage 2-8°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jol Duperray, et al. J Cosmet Dermatol. The effects of the oral supplementation of L-Cystine associated with reduced L-Glutathione-GSH on human skin pigmentation: a randomized, double-blinded, benchmark- and placebo-controlled clinical trial

[2] Dongjune Kim, et al. PLoS One. Lysis of arterial thrombi by perfusion of N,N'-Diacetyl-L-cystine (DiNAC)

[3] Yanhui Yang, et al. Bioorg Med Chem Lett. Design, synthesis, and evaluation of l-cystine diamides as l-cystine crystallization inhibitors for cystinuria

[4] Longqin Hu, et al. J Med Chem. l-Cystine Diamides as l-Cystine Crystallization Inhibitors for Cystinuria

[5] J Kunert. Acta Univ Palacki Olomuc Fac Med. Utilization of L-cystine as a source of carbon and nitrogen by various fungi

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Keywords: L-Cystine supplier, inhibitors, activators


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