All AbMole products are for research use only, cannot be used for human consumption.
JNJ-47117096 is potent and selective MELK inhibitor with IC50 of 23 nM. JNJ-47117096 (MELK-T1) suppresses the proliferation of Flt3-driven Ba/F3 cell lines, with an IC50 of 1.5 μM in the absence of IL-3, while no inhibitory activity is observed in the presence of IL-3. JNJ-47117096 (MELK-T1, 10 μM) delays the progression of MCF-7 cells through S-phase. JNJ-47117096 (3, 10 μM) results in a growth arrest and a senescent phenotype.
| Molecular Weight | 362.42 |
| Formula | C21H22N4O2 |
| CAS Number | 1610586-62-3 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related MELK Products |
|---|
| OTSSP167 hydrochloride
OTSSP167 hydrochloride is a highly potent, selective MELK inhibitor with IC50 of 0.41 nM. |
| MELK-8a hydrochloride
MELK-8a hydrochloride is a novel maternal embryonic leucine zipper kinase (MELK) inhibitor with an IC50 of 2 nM. |
| JNJ-47117096 hydrochloride
JNJ-47117096 hydrochloride is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
