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JNJ-47117096 is potent and selective MELK inhibitor with IC50 of 23 nM. JNJ-47117096 (MELK-T1) suppresses the proliferation of Flt3-driven Ba/F3 cell lines, with an IC50 of 1.5 μM in the absence of IL-3, while no inhibitory activity is observed in the presence of IL-3. JNJ-47117096 (MELK-T1, 10 μM) delays the progression of MCF-7 cells through S-phase. JNJ-47117096 (3, 10 μM) results in a growth arrest and a senescent phenotype.
| Molecular Weight | 362.42 |
| Formula | C21H22N4O2 |
| CAS Number | 1610586-62-3 |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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