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ITX3

Cat. No. M7851

All AbMole products are for research use only, cannot be used for human consumption.

ITX3 Structure

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Quality Control & Documentation
Biological Activity

ITX3 is a specific inhibitor of endogenous TrioN activity acting on the GEF domain and selective cell active inhibitor of the Trio/RhoG/Rac1 pathway. The compound is active in whole cell assay where it inhibits the formation of TrioN-dependent cell structures. ITX3 appears to be specific for TrioN inhibition rather than other RhoGEFs.

Chemical Information
Molecular Weight 371.45
Formula C22H17N3OS
CAS Number 347323-96-0
Solubility (25°C) DMSO: ≥4 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kiran A Vaidya, et al. Rac1 mediates Cadherin-11 induced cellular pathogenic processes in aortic valve calcification

[2] Shivangi, et al. A multifactorial assessment of the SRP pathway constituent FtsY as a vital mycobacterial constituent

[3] Kyonghee Son, et al. Supervillin binds the Rac/Rho-GEF Trio and increases Trio-mediated Rac1 activation

[4] Yan Yan, et al. Kalirin-9 and Kalirin-12 Play Essential Roles in Dendritic Outgrowth and Branching

[5] Nathalie Bouquier, et al. A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway

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  Catalog
Abmole Inhibitor Catalog




Keywords: ITX3 supplier, inhibitors, activators

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