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iRGD peptide

Cat. No. M13755
iRGD peptide Structure


Size Price Availability Quantity
1mg USD 80  USD80 In stock
5mg USD 330  USD330 In stock
10mg USD 580  USD580 In stock
25mg USD 880  USD880 In stock
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Quality Control & Documentation
Biological Activity

iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of drugs by first binding to av integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties.

Chemical Information
Molecular Weight 948.04
Formula C35H57N13O14S2
CAS Number 1392278-76-0
Solubility (25°C) Water ≥ 50 mg/mL
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Huipu Li, et al. Int J Nanomedicine. iRGD Peptide-Mediated Liposomal Nanoparticles with Photoacoustic/Ultrasound Dual-Modality Imaging for Precision Theranostics Against Hepatocellular Carcinoma

[2] Sujin Kang, et al. Polymers (Basel). iRGD Peptide as a Tumor-Penetrating Enhancer for Tumor-Targeted Drug Delivery

[3] Houdong Zuo. J Oncol. iRGD: A Promising Peptide for Cancer Imaging and a Potential Therapeutic Agent for Various Cancers

[4] Hong-Jun Cho, et al. J Control Release. Theranostic iRGD peptide containing cisplatin prodrug: Dual-cargo tumor penetration for improved imaging and therapy

[5] Hong Yin, et al. Mol Med Rep. iRGD as a tumor‑penetrating peptide for cancer therapy (Review)

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Keywords: iRGD peptide, c(CRGDKGPDC) supplier, Integrin, inhibitors, activators

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