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Insulin icodec 

Cat. No. M31269
Insulin icodec  Structure
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Biological Activity

Insulin icodec is a basal insulin analog. Insulin icodec can be used for the research of type 2 diabetes.

Chemical Information
Molecular Weight 6380.26
Formula C280H435N71O87S6
CAS Number 1188379-43-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Awadhesh Kumar Singh, et al. Diabetes Metab Syndr. Once-weekly basal insulin icodec: Looking ONWARDS from pharmacology to clinical trials

[2] Athena Philis-Tsimikas, et al. Diabetes Obes Metab. Rationale and design of the phase 3a development programme (ONWARDS 1-6 trials) investigating once-weekly insulin icodec in diabetes

[3] Erica Nishimura, et al. BMJ Open Diabetes Res Care. Molecular and pharmacological characterization of insulin icodec: a new basal insulin analog designed for once-weekly dosing

[4] Harpreet S Bajaj, et al. Diabetes Care. Switching to Once-Weekly Insulin Icodec Versus Once-Daily Insulin Glargine U100 in Type 2 Diabetes Inadequately Controlled on Daily Basal Insulin: A Phase 2 Randomized Controlled Trial

[5] Ildiko Lingvay, et al. Diabetes Care. A Randomized, Open-Label Comparison of Once-Weekly Insulin Icodec Titration Strategies Versus Once-Daily Insulin Glargine U100

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