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INDY is a dYRK1A/B inhibitor (IC50 values of DYRK1B and DYRKA are 0.23 and 0.24 μM, respectively). Binds at the ATP binding site of the enzyme. Reverse abnormal Tau phosphorylation and rescue suppressed calcineurin /NFAT signal transduction. Impaired the self-renewing ability of neural stem cells in the subventricular region. Also available as a precursor compound, proINDY.
| Molecular Weight | 235.3 |
| Formula | C12H13NO2S |
| CAS Number | 1169755-45-6 |
| Solubility (25°C) | DMSO 23.53 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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