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Indomethacin sodium hydrate (Indometacin sodium hydrate) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. Indomethacin sodium hydrate disrupts autophagic flux by disturbing the normal functioning of lysosomes.
| Molecular Weight | 433.82 |
| CAS Number | 74252-25-8 |
| Solubility (25°C) | Water 25 mg/mL DMSO 10 mg/mL |
| Storage | 2-8°C, protect from light, sealed |
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PPOH, a fatty acid derivative, is a selective cyclooxygenase (COX) inhibitor that inhibits arachidonic acid cyclooxygenase activity in renal cortical microsomes. |
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