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IHVR-19029 

Cat. No. M28463

All AbMole products are for research use only, cannot be used for human consumption.

IHVR-19029  Structure

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Quality Control & Documentation
Biological Activity

IHVR-19029 is a potent endoplasmic reticulum (ER) α-glucosidases I and II inhibitor, with an IC50 of 0.48 μM for ER a-glucosidase I. IHVR-19029 efficiently blocks the replication of several hemorrhagic fever viruses, such as Dengue virus (DENV), Ebola virus (EBOV) and Rift Valley fever virus. The combination of IHVR-19029 with Favipiravir improves the antiviral efficacy.

Chemical Information
Molecular Weight 443.62
Formula C23H45N3O5
CAS Number 1447464-73-4
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Julia Ma, et al. Antiviral Res. Enhancing the antiviral potency of ER α-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo

[2] Julia Ma, et al. ACS Med Chem Lett. Ester Prodrugs of IHVR-19029 with Enhanced Oral Exposure and Prevention of Gastrointestinal Glucosidase Interaction

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  Catalog
Abmole Inhibitor Catalog




Keywords: IHVR-19029  supplier, Glucosidase, inhibitors, activators

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