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ICG-OSu

Cat. No. M21459
ICG-OSu Structure
Synonym:

ICG NHS ester

Size Price Availability Quantity
5mg USD 450  USD450 In stock
10mg USD 700  USD700 In stock
25mg USD 1350  USD1350 In stock
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Quality Control & Documentation
Biological Activity

ICG-OSu (ICG NHS ester) is a near infrared fluorescent agent with amine reactivity that is widely used in the design of in vivo imaging probes. Em >750 nm infrared, Ex >750 nm infrared.

Chemical Information
Molecular Weight 828.04
Formula C49H53N3O7S
CAS Number 1622335-40-3
Solubility (25°C) DMSO : 25 mg/mL
Storage -20℃, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Elvira Garca de Jaln, et al. Mol Imaging Biol. Comparison of Five Near-Infrared Fluorescent Folate Conjugates in an Ovarian Cancer Model

[2] Ying Zhou, et al. Bioconjug Chem. A Novel Near-Infrared Fluorescent Probe TMTP1-PEG4-ICG for in Vivo Tumor Imaging

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