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Ibuprofen Lysine

Cat. No. M20850
Ibuprofen Lysine Structure
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Biological Activity

Ibuprofen Lysine is a non-steroidal anti-inflammatory drug.

Chemical Information
Molecular Weight 352.47
Formula C19H32N2O4
CAS Number 57469-77-9
Solubility (25°C) Water 71 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rocio Bueno-Perez, et al. Chem Commun (Camb). Enantioselective adsorption of ibuprofen and lysine in metal-organic frameworks

[2] Andrew R Moore, et al. Pain. Faster, higher, stronger? Evidence for formulation and efficacy for ibuprofen in acute pain

[3] M J Sheffield, et al. J Perinatol. Ibuprofen lysine administration to neonates with a patent ductus arteriosus: effect on platelet plug formation assessed by in vivo and in vitro measurements

[4] Vinita B Pai, et al. Pharmacotherapy. Ibuprofen lysine for the prevention and treatment of patent ductus arteriosus

[5] W Martin, et al. Biopharm Drug Dispos. Pharmacokinetics and absolute bioavailability of ibuprofen after oral administration of ibuprofen lysine in man

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