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Hydroxytyrosol 4-O-glucoside

Cat. No. M17117
Hydroxytyrosol 4-O-glucoside Structure
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Biological Activity

Hydroxytyrosol 4-O-glucoside

Chemical Information
CAS Number 54695-80-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Cinzia Benincasa, et al. Front Nutr. Qualitative and Quantitative Analysis of Phenolic Compounds in Spray-Dried Olive Mill Wastewater

[2] Hakime Hlya Orak, et al. Molecules. Genotype-Related Differences in the Phenolic Compound Profile and Antioxidant Activity of Extracts from Olive ( Olea europaea L.) Leaves

[3] Eleni Melliou, et al. J Agric Food Chem. Ultrahigh-pressure liquid chromatography triple-quadrupole tandem mass spectrometry quantitation of polyphenols and secoiridoids in california-style black ripe olives and dry salt-cured olives

[4] Evgenia Mousouri, et al. J Agric Food Chem. Isolation of megaritolactones and other bioactive metabolites from 'megaritiki' table olives and debittering water

[5] Hassan K Obied, et al. Anal Chim Acta. Chemical screening of olive biophenol extracts by hyphenated liquid chromatography

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