Hydroxycitric acid tripotassium hydrate, the main active ingredient of Garcinia Cambogia, competitively inhibits ATP citrate lyase activity. In addition, Hydroxycitric acid tripotassium hydrate inhibits stone formation and HIF, and has antioxidant, anti-inflammatory and antitumor activities.
| Molecular Weight | 324.41 |
| Formula | C6H7K3O8 |
| CAS Number | 6100-05-6 |
| Form | Solid |
| Solubility (25°C) | Water 100 mg/mL |
| Storage | 4°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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