Human transferrin is a key nutrient in cultured mammalian cells. Human transferrin is composed of a 77kDa glycoprotein containing 679 amino acids. This product is the key to long term cell culture in vivo. It can bind contaminated metal ions in the medium to achieve the effect of detoxification agent. This product is often used as a nutrient in fermentation media to facilitate the production of recombinant proteins and biopharmaceuticals. Other common uses of this product are molecular weight, affinity purification of human transferrin antibody, and cell entry as a receptor-mediated transfection molecule such as DNA.
| Formula | C16H22N6O4 |
| CAS Number | 11096-37-0 |
| Solubility (25°C) | Soluble in water |
| Storage | 2-8°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Claire Booyjzsen, et al. Biochim Biophys Acta. Fibrillation of transferrin
[5] M I Kamboh, et al. Hum Hered. Human transferrin polymorphism
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