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Human Transferrin

Cat. No. M19965
Human Transferrin Structure
Synonym:

Siderophilin; partially saturated

Size Price Availability Quantity
50mg USD 250  USD250 In stock
100mg USD 365  USD365 In stock
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Quality Control & Documentation
  • Purity: >98%, Endotoxin <0.025 EU/mg
  • COA
  • MSDS
Biological Activity

Human transferrin is a key nutrient in cultured mammalian cells. Human transferrin is composed of a 77kDa glycoprotein containing 679 amino acids. This product is the key to long term cell culture in vivo. It can bind contaminated metal ions in the medium to achieve the effect of detoxification agent. This product is often used as a nutrient in fermentation media to facilitate the production of recombinant proteins and biopharmaceuticals. Other common uses of this product are molecular weight, affinity purification of human transferrin antibody, and cell entry as a receptor-mediated transfection molecule such as DNA.

Chemical Information
Formula C16H22N6O4
CAS Number 11096-37-0
Solubility (25°C) Soluble in water
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Claire Booyjzsen, et al. Biochim Biophys Acta. Fibrillation of transferrin

[2] Martin E Brandsma, et al. Biotechnol Adv. Recombinant human transferrin: beyond iron binding and transport

[3] Jeremy Wally, et al. Biometals. A structural comparison of human serum transferrin and human lactoferrin

[4] Peter T Gomme, et al. Drug Discov Today. Transferrin: structure, function and potential therapeutic actions

[5] M I Kamboh, et al. Hum Hered. Human transferrin polymorphism

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Keywords: Human Transferrin, Siderophilin; partially saturated supplier, Cell Culture, inhibitors, activators


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