Free shipping on all orders over $ 500

Histidylprolineamide

Cat. No. M43218
Histidylprolineamide Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

Histidylprolineamide (His-pro-amide) is a reactive amide, an intermediate in the histidine metabolic pathway.

Chemical Information
Molecular Weight 251.28
Formula C11H17N5O2
CAS Number 33605-69-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] A Enjalbert et al. J Physiol (Paris). [Effect of neuropeptides on prolactin secretion by the adenohypophysis (author's transl)]

[2] P Browne et al. Eur J Biochem. An evaluation of the role of a pyroglutamyl peptidase, a post-proline cleaving enzyme and a post-proline dipeptidyl amino peptidase, each purified from the soluble fraction of guinea-pig brain, in the degradation of thyroliberin in vitro

[3] B O'Connor et al. Eur J Biochem. Post-proline dipeptidyl-aminopeptidase from synaptosomal membranes of guinea-pig brain. A possible role for this activity in the hydrolysis of His-ProNH2, arising from the action of synaptosomal membrane pyroglutamate aminopeptidase on thyroliberin

[4] J Møss et al. J Pharm Pharmacol. Kinetics and mechanism of the facile cyclization of histidyl-prolineamide to cyclo (His-Pro) in aqueous solution and the competitive influence of human plasma

[5] T Matsui et al. J Biol Chem. Metabolism of thyrotropin releasing hormone in brain extracts. Isolation and characterization of an imidopeptidase for histidylprolineamide

Related Products
Isothiuronium

Isothiouronium is a functional group, it is the acid salt of isothiourea.
Sultosilic acid, piperazine salt

Sultosilic acid piperazine salt is a compound with lowering lipid activity. It causes significant shortening of the euglobulin lysis time and a significant diminution of platelet adhesiveness, as well as statistically significant decrease of triglycerides, total cholesterol, beta- and pre-beta-cholesterol and an increase of alpha-cholesterol.
Ipamorelin

Ipamorelin (NNC-26-0161) is a a novel and potent ghrelin mimetic peptide compound that counteracts glucocorticoid-induced decrease in bone formation of adult rats.
PRGL493

PRGL493 is a potent and selective long-chain acyl-CoA synthetase 4 (ACSL4) inhibitor. PRGL493 blocks cell proliferation and tumor growth in both breast and prostate cellular and animal models.

Hercynine

Hercynine is a natural product, found in the fine leaf algae, Schizosaccharomyces cerevisiae and honey bees, and is a precursor of L-(+)-ergothioneine.
  Catalog
Abmole Inhibitor Catalog




Keywords: Histidylprolineamide supplier, inhibitors, activators

 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.