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Hexahydrocurcumin

Cat. No. M17209
Hexahydrocurcumin Structure
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Biological Activity

Hexahydrocurcumin

Chemical Information
CAS Number 36062-05-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Toshio Niwa, et al. Biol Pharm Bull. Production of Optically Active Hexahydrocurcumin by Human Intestinal Bacterium in Vitro

[2] Pranglada Jearjaroen, et al. Neurotox Res. Inhibitory Effect of Hexahydrocurcumin on Memory Impairment and Amyloidogenesis in Dexamethasone-Treated Mice

[3] Piyawadee Wicha, et al. Pharmacol Rep. Hexahydrocurcumin alleviated blood-brain barrier dysfunction in cerebral ischemia/reperfusion rats

[4] Yiyuan Huang, et al. Arch Biochem Biophys. Biological and pharmacological effects of hexahydrocurcumin, a metabolite of curcumin

[5] Chien-Neng Kuo, et al. Int Ophthalmol. Anti-angiogenic effect of hexahydrocurcumin in rat corneal neovascularization

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