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Heteropeucenin 7-methyl ether

Cat. No. M17113
Heteropeucenin 7-methyl ether Structure
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Biological Activity

Heteropeucenin 7-methyl ether

Chemical Information
CAS Number 26213-95-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jonghwan Jegal, et al. Nutrients. Inhibitory Effects of Luteolin 7-Methyl Ether Isolated from Wikstroemia ganpi on Tnf-A/Ifn-Γ Mixture-Induced Inflammation in Human Keratinocyte

[2] Narayan D Chaurasiya, et al. Molecules. Selective Inhibition of Human Monoamine Oxidase B by Acacetin 7-Methyl Ether Isolated from Turnera diffusa (Damiana)

[3] Yuyan Qi, et al. Exp Ther Med. Novel triazole analogs of apigenin-7-methyl ether exhibit potent antitumor activity against ovarian carcinoma cells via the induction of mitochondrial-mediated apoptosis

[4] Yue-Mei Chen, et al. Zhongguo Zhong Yao Za Zhi. [Chemical constituents from Murraya euchrestifolia]

[5] Vyacheslav V Uzbekov, et al. Acta Crystallogr Sect E Struct Rep Online. Lacinilene C 7-methyl ether

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