Hematin, an iron-containing porphyrin, inhibits the activity of clotting factors and also fibrin clot lysis through the mechanism of binding to and inactivation of hemostatic proteins. Hematin can be used for the research of acute porphyrias and cancer.
| Molecular Weight | 633.49 |
| Formula | C34H33FeN4O5 |
| CAS Number | 15489-90-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 1.43 mg/mL (ultrasonic and warming and heat to 70°C) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] J W DANIEL, et al. J Bacteriol. Hematin--requiring plasmodial myxomycete
[3] G Blauer, et al. Biochem Mol Biol Int. B-hematin
[4] C A Pierach. Semin Liver Dis. Hematin therapy for the porphyric attack
[5] D Green, et al. J Lab Clin Med. Hematin: effects on hemostasis
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