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HDS 029

Cat. No. M6789

All AbMole products are for research use only, cannot be used for human consumption.

HDS 029 Structure

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Quality Control & Documentation
Biological Activity

HDS 029 is a potent inhibitor of the ErbB receptor family (IC50 values are 0.3, 0.5 and 1.1 nM for ErbB1 (EGFR), ErbB4 and ErbB2 respectively). Inhibits EGF-induced erbB1 autophosphorylation in NIH3T3 cells and heregulin-stimulated ErbB autophosphorylation in MDA-MB-453 human breast carcinoma cells (IC50 values are 2.5 and 24 nM respectively).

Chemical Information
Molecular Weight 355.76
Formula C17H11ClFN5O
CAS Number 881001-19-0
Solubility (25°C) DMSO 8.89 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Clem, et al. Mol Cancer Ther. Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth.

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  Catalog
Abmole Inhibitor Catalog




Keywords: HDS 029 supplier, inhibitors, activators

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