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GZD824 Dimesylate

Cat. No. M2749
GZD824 Dimesylate Structure
Synonym:

Olverembatinib Dimesylate

Size Price Availability Quantity
5mg USD 70  USD70 In stock
10mg USD 110  USD110 In stock
25mg USD 220  USD220 In stock
50mg USD 350  USD350 In stock
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Quality Control & Documentation
Biological Activity

GZD824 is a third-generation oral effective BCR-ABL inhibitor, acting on BCR-ABL (WT) and BCR-ABL (T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.

Chemical Information
Molecular Weight 724.77
Formula C29H27F3N6O.2CH4O3S
CAS Number 1421783-64-3
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: GZD824 Dimesylate, Olverembatinib Dimesylate supplier, Src-bcr-Abl, inhibitors, activators


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