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GSK 4716

Cat. No. M6165
GSK 4716 Structure
Size Price Availability Quantity
5mg USD 49  USD49 In stock
10mg USD 75  USD75 In stock
50mg USD 320  USD320 In stock
100mg USD 565  USD565 In stock
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Quality Control & Documentation
Biological Activity

GSK 4716 is a selective agonist with estrogen-related receptors ERRβ and ERRγ.

Chemical Information
Molecular Weight 282.33
Formula C17H18N2O2
CAS Number 101574-65-6
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Saili KS, et al. Toxicology. Neurodevelopmental low-dose bisphenol A exposure leads to early life-stage hyperactivity and learning deficits in adult zebrafish.

[2] Kim Y, et al. J Comb Chem. Efficient discovery of selective small molecule agonists of estrogen-related receptor gamma using combinatorial approach.

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Keywords: GSK 4716 supplier, Estrogen Receptor, inhibitors, activators


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