All AbMole products are for research use only, cannot be used for human consumption.
In vitro: GO-203 inhibits MUC1-C homodimerization which blocks its oncogenic function. Treatment of MUC1-overexpressing SKCO-1 and Colo-205 colon cancer cells with GO-203 is associated with downregulation of the TP53-inducible glycolysis and apoptosis regulator (TIGAR) protein. GO-203 regulates AKT-S6K1-elF4A signaling in colorectal cancer cells. Targeting MUC1-C with GO-203 inhibits p-AKT in colorectal cancer cells. GO-203 treatment also results in increases in reactive oxygen species (ROS) and loss of mitochondrial transmembrane potential.
In vivo: GO-203 is effective in inhibiting growth and survival of MUC1-positive colorectal cancer cells in mouse xenograft models. It is also effective in xenografts models of breast, prostate, lung and certain hematologic malignancy.
Biochem Pharmacol. 2025 Jun 06; .
Involvement of ADAM17-dependent MUC1-CT activation in TGF-β-induced EZH2 expression in human lung fibroblasts and in ovalbumin-induced airway fibrosis in mice
GO-203 purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | Human SW480 and LOVO colorectal cancer cells |
| Preparation method | To assess cell viability, 20,000–30,000 cells are plated and cultured for 48 h. GO-203 and CP-2 are added at 5 μM every day for six days. Cell viability is measured by trypan blue exclusion. |
| Concentrations | 5 μM |
| Incubation time | 48 h |
| Animal Experiment | |
|---|---|
| Animal models | BALB/c nu/nu male/female mice with xenograft tumor |
| Formulation | PBS |
| Dosages | 18 mg/kg |
| Administration | i.p. |
| Molecular Weight | 2426.77 |
| Formula | C87H170N52O19S2.C2HF3O2 |
| CAS Number | 1222186-26-6 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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