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GNE-272

Cat. No. M25514

All AbMole products are for research use only, cannot be used for human consumption.

GNE-272 Structure

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Quality Control & Documentation
Biological Activity

GNE-272 is a potent and selective CBP/EP300 inhibitor with IC50 values of 0.02, 0.03 and 13 μM for CBP, EP300 and BRD4, respectively. GNE-272 is also a selective in vivo probe for CBP/EP300.

Chemical Information
Molecular Weight 424.47
Formula C22H25FN6O2
CAS Number 1936428-93-1
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kwong Wah Lai, et al. Bioorg Med Chem Lett. Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300

[2] F Anthony Romero, et al. J Med Chem. GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)

[3] Terry D Crawford, et al. J Med Chem. Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300

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  Catalog
Abmole Inhibitor Catalog




Keywords: GNE-272 supplier, Epigenetic Reader Domain, inhibitors, activators

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