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Gly-Gly-Tyr-Arg

Cat. No. M10221
Gly-Gly-Tyr-Arg Structure
Synonym:

Papain Inhibitor

Size Price Availability
25mg USD 175  USD175 4-7 Days
50mg USD 245  USD245 4-7 Days
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Quality Control & Documentation
Biological Activity

Gly-Gly-Tyr-Arg

Chemical Information
Molecular Weight 451.48
Formula C19H29N7O6
CAS Number 70195-20-9
Solubility (25°C) Water 2 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ting Sun, et al. Nanomaterials (Basel). A Graphene Oxide-Based Fluorescent Platform for Probing of Phosphatase Activity

[2] Khaled A Mahmoud, et al. ACS Appl Mater Interfaces. Preparation of well-dispersed gold/magnetite nanoparticles embedded on cellulose nanocrystals for efficient immobilization of papain enzyme

[3] Alan M Piwowar, et al. Anal Chem. Effects of cryogenic sample analysis on molecular depth profiles with TOF-secondary ion mass spectrometry

[4] Hideya Kawasaki, et al. Anal Bioanal Chem. Sulfonate group-modified FePtCu nanoparticles as a selective probe for LDI-MS analysis of oligopeptides from a peptide mixture and human serum proteins

[5] N M Domigan, et al. J Biol Chem. Chlorination of tyrosyl residues in peptides by myeloperoxidase and human neutrophils

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Keywords: Gly-Gly-Tyr-Arg, Papain Inhibitor supplier, inhibitors, activators


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