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Glumetinib

Cat. No. M9521
Glumetinib Structure
Synonym:

SCC244

Size Price Availability Quantity
5mg USD 140  USD140 In stock
10mg USD 203  USD203 In stock
25mg USD 375  USD375 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Glumetinib inhibits c-Met signal transduction and thereby suppresses the c-Met-dependent neoplastic phenotype of tumor and endothelial cells. Glumetinib (SCC244) showed subnanomolar potency against c-Met kinase activity and high selectivity versus 312 other tested protein kinases, making it one of the most selective c-Met inhibitors.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 459.48
Formula C21H17N9O2S
CAS Number 1642581-63-2
Purity >98%
Solubility DMSO ≥ 30 mg/mL
Storage at -20°C
References

[1] Jing Ai, et al. Mol Cancer Ther. Preclinical Evaluation of SCC244 (Glumetinib), a Novel, Potent, and Highly Selective Inhibitor of c-Met in MET-dependent Cancer Models.

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Keywords: Glumetinib, SCC244 supplier, c-Met, inhibitors

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