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GLP-1(7-37)

Cat. No. M11207
GLP-1(7-37) Structure
Synonym:

Insulinotropin (human);Peptide GLP-1 (human glucose-lowering peptide-1)

Size Price Availability
1mg USD 250  USD250 Out of stock
5mg USD 420  USD420 Out of stock
10mg USD 650  USD650 Out of stock
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Quality Control & Documentation
Biological Activity

Glp-1 (7-37) is an intestinal insulin hormone that enhances glucose-induced insulin secretion.

Chemical Information
Molecular Weight 3355.67
Formula C151H228N40O47
CAS Number 106612-94-6
Solubility (25°C) Water ≥ 20 mg/mL
Storage -20°C,protect from light , dry , sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jinhua Zhang, et al. J Pept Sci. Efficient synthesis of Aib 8 -Arg 34 -GLP-1 (7-37) by liquid-phase fragment condensation

[2] Seyed Ebrahim Alavi, et al. Bioconjug Chem. Developing GLP-1 Conjugated Self-Assembling Nanofibers Using Copper-Catalyzed Alkyne-Azide Cycloaddition and Evaluation of Their Biological Activity

[3] No authors listed. Mol Cell Endocrinol. Liraglutide

[4] Torsten P Vahl, et al. J Clin Endocrinol Metab. Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans

[5] H C Fehmann, et al. Mol Cell Endocrinol. Glucagon-like peptide-1(7-37)/(7-36)amide is a new incretin

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Keywords: GLP-1(7-37), Insulinotropin (human);Peptide GLP-1 (human glucose-lowering peptide-1) supplier, Glucagon Receptor, inhibitors, activators

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