Glp-1 (7-37) is an intestinal insulin hormone that enhances glucose-induced insulin secretion.
|Solubility (25°C)||Water ≥ 20 mg/mL|
|Storage||-20°C,protect from light , dry , sealed|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Jinhua Zhang, et al. J Pept Sci. Efficient synthesis of Aib 8 -Arg 34 -GLP-1 (7-37) by liquid-phase fragment condensation
 Seyed Ebrahim Alavi, et al. Bioconjug Chem. Developing GLP-1 Conjugated Self-Assembling Nanofibers Using Copper-Catalyzed Alkyne-Azide Cycloaddition and Evaluation of Their Biological Activity
 No authors listed. Mol Cell Endocrinol. Liraglutide
 Torsten P Vahl, et al. J Clin Endocrinol Metab. Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans
 H C Fehmann, et al. Mol Cell Endocrinol. Glucagon-like peptide-1(7-37)/(7-36)amide is a new incretin
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|GLP-1(7-36), amide acetate
GLP-1(7-36), amide acetate is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells.
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