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Gemcabene (PD-72953) is a first-in-class PPARα agonist, lipid-lowering agent. It lowers density lipoprotein cholesterol (LDL-C), lowers triglycerides and increases high density lipoprotein cholesterol (HDL-C), and lowers the pro-inflammatory acute phase protein, C-reactive protein (CRP), showing anti-inflammatory activity.
| Molecular Weight | 302.41 |
| Formula | C16H30O5 |
| CAS Number | 183293-82-5 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Jaap W Mandema, et al. AAPS J. Model-based development of gemcabene, a new lipid-altering agent
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