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Gap19 TFA is a nonapeptide derived from the cytoplasmic loop (CL) of Cx43 and acts as a selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA blocks Cx43 hemichannels without inhibiting gap junctions (GJs) at IC50 of 6.5 μM when applied intracellulary.
| Molecular Weight | 1275.46 |
| Formula | C57H97F3N14O15 |
| CAS Number | 1507930-57-5 (free base) |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL Water 100 mg/mL |
| Storage | Store at ≤ -20°C, dry, sealed |
[1] Meixi Quan, et al. Circ Res. MST1 Suppresses Disturbed Flow Induced Atherosclerosis
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