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γ-Cyclodextrin

Cat. No. M10260
γ-Cyclodextrin Structure
Synonym:

γCD

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Quality Control & Documentation
Biological Activity

Cyclodextrins may be used to form inclusion complexes with a variety of drug molecules, resulting primarily in improvements to dissolution and bioavailability owing to enhanced solubility and improved chemical and physical stability.

Chemical Information
Molecular Weight 1297.12
Formula C48H80O40
CAS Number 17465-86-0
Form Solid
Solubility (25°C) 1 M NaOH: 25 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sophia E Hollow, et al. Chem Commun (Camb). Encapsulation of closo-dodecaiodododecaborate in 2-hydroxypropyl-γ-cyclodextrin prevents hemolysis

[2] Hongzhen Bai, et al. Nat Commun. Cyclodextrin-based host-guest complexes loaded with regorafenib for colorectal cancer treatment

[3] Hangyan Ji, et al. Biotechnol Prog. Application of cyclodextrinase in non-complexant production of γ-cyclodextrin

[4] Phennapha Saokham, et al. Int J Pharm. γ-Cyclodextrin

[5] Stiliana Pereva, et al. J Agric Food Chem. Cyclodextrin-Based Solid-Gas Clathrates

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Keywords: γ-Cyclodextrin, γCD supplier, Metabolite/Endogenous Metabolite, inhibitors, activators


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