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Gallic acid hydrate

Cat. No. M14080
Gallic acid hydrate Structure
Synonym:

3,4,5-Trihydroxybenzoic acid hydrate

Size Price Availability Quantity
100mg USD 58  USD58 In stock
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Quality Control & Documentation
Biological Activity

Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2). Gallic acid hydrate has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities.

Chemical Information
Molecular Weight 188.13
CAS Number 5995-86-8
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rumpa Pal, et al. π-Hole bonding in a new co-crystal hydrate of gallic acid and pyrazine: static and dynamic charge density analysis

[2] Lin Shi, et al. New insights into the different adsorption kinetics of gallic acid and tannic acid on minerals via 1 H NMR relaxation of bound water

[3] Lus Cruz, et al. Impact of a Water-Soluble Gallic Acid-Based Dendrimer on the Color-Stabilizing Mechanisms of Anthocyanins

[4] L Vella-Zarb, et al. Crystal water as the mol-ecular glue for obtaining different co-crystal ratios: the case of gallic acid tris-caffeine hexa-hydrate

[5] Qiang Cai, et al. Investigation into structure and dehydration dynamic of gallic acid monohydrate: A Raman spectroscopic study

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Keywords: Gallic acid hydrate, 3,4,5-Trihydroxybenzoic acid hydrate supplier, COX, inhibitors, activators


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