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G140 

Cat. No. M29550

All AbMole products are for research use only, cannot be used for human consumption.

G140  Structure

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Quality Control & Documentation
Biological Activity

G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity.

Chemical Information
Molecular Weight 379.24
Formula C17H16Cl2N4O2
CAS Number 2369751-07-3
Form Solid
Solubility (25°C) DMSO 250 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Soo-Yon Rhee, et al. Antiviral Res. Genotypic correlates of resistance to the HIV-1 strand transfer integrase inhibitor cabotegravir

[2] Davide Ferrari, et al. Antivir Ther. Increased dose of dolutegravir as a potential rescue therapy in multi-experienced patients

[3] Jing Zou, et al. J Virol. Mapping the Interactions between the NS4B and NS3 proteins of dengue virus

[4] Mathieu Métifiot, et al. Viruses. Resistance to integrase inhibitors

[5] Elaine M Stockx, et al. BMC Neurosci. The development of descending projections from the brainstem to the spinal cord in the fetal sheep

  Catalog
Abmole Inhibitor Catalog




Keywords: G140  supplier, Cyclic GMP-AMP Synthase, inhibitors, activators

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