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G-5555

Cat. No. M13706
G-5555 Structure
Size Price Availability
5mg USD 110  USD110 4-7 Days
10mg USD 160  USD160 4-7 Days
25mg USD 360  USD360 4-7 Days
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Quality Control & Documentation
Biological Activity

G-5555 is a potent p21-activated kinase 1 (PAK1) inhibitor with Kis of 3.7 nM and 11 nM for PAK1 and PAK2, respectively.

Chemical Information
Molecular Weight 492.96
CAS Number 1648863-90-4
Solubility (25°C) DMSO 25 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hai-Feng Qiao, et al. J Reprod Immunol. Retraction notice to "G-5555 synergized miR-485-5p to alleviate cisplatin resistance in ovarian cancer cells via Pi3k/Akt signaling pathway" [J. Reprod. Immunol. 140C (2020) 103129]

[2] Roberta Tesch, et al. J Med Chem. Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors

[3] Hai-Feng Qiao, et al. J Reprod Immunol. G-5555 synergized miR-485-5p to alleviate cisplatin resistance in ovarian cancer cells via Pi3k/Akt signaling pathway

[4] Christina M Knippler, et al. Endocr Relat Cancer. MAPK- and AKT-activated thyroid cancers are sensitive to group I PAK inhibition

[5] Chudi O Ndubaku, et al. ACS Med Chem Lett. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety

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  Catalog
Abmole Inhibitor Catalog




Keywords: G-5555 supplier, PAK, inhibitors, activators


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