Free shipping on all orders over $ 500

Frangulin B

Cat. No. M16213
Frangulin B Structure
Size Price Availability Quantity
5mg USD 550  USD550 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Frangulin B

Chemical Information
CAS Number 14101-04-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Magdalena Westermann, et al. Chem Biol Interact. Inhibition of human carbonyl reducing enzymes by plant anthrone and anthraquinone derivatives

[2] Immanuel Rosenthal, et al. J Nat Prod. Validated method for the analysis of frangulins A and B and glucofrangulins A and B using HPLC and UHPLC

[3] B L Wei, et al. Planta Med. In vitro anti-inflammatory effects of quercetin 3-O-methyl ether and other constituents from Rhamnus species

[4] C M Teng, et al. Thromb Haemost. Frangulin B, an antagonist of collagen-induced platelet aggregation and adhesion, isolated from Rhamnus formosana

[5] H Wagner, et al. Z Naturforsch C Biosci. [Investigations of the anthrachinone-glycosides from Rhamnus frangula L. 3. 6-O (D-apiofuranosyl)-1,6,8-trihydroxy-3-methyl-anthrachinone, a new glycoside (frangulin B) from the bark of Rhamnus frangula L (author's transl)]

Related Anthraquinones Products
Questinol

Questinol

Frangulin A

Frangulin A

Rubanthrone A

Rubanthrone A

Chrysoobtusin

Chrysoobtusin

Floribundone 1

Floribundone 1

  Catalog
Abmole Inhibitor Catalog




Keywords: Frangulin B supplier, Anthraquinones, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.