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Framycetin

Cat. No. M11458
Framycetin Structure
Synonym:

Neomycin B; Fradiomycin B

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Biological Activity

Framycetin (Neomycin B) is an aminoglycoside antibiotic, which is an effective inhibitor of RNase P cleavage activity with Ki of 35 μM. Framycetin competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin inhibited Hammerhead ribozyme with Ki value of 13.5 μM. Framycetin is a 5 "-Azido neomycin B precursor that binds to the Drosha site in Mir-525 and can be used for hepatic encephalopathy and enteropathogenic E. coli infection.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 614.64
Formula C23H46N6O13
CAS Number 119-04-0
Purity
Solubility DMSO ≥ 40 mg/mL
Storage 2-8°C
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Sequence:Ac-D2Nal-DCpa-DPal-Ser-Lys(nicotinoyl)-DLys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-DAla-NH2

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Keywords: Framycetin, Neomycin B; Fradiomycin B supplier, inhibitors

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