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Framycetin (Neomycin B) is an aminoglycoside antibiotic, which is an effective inhibitor of RNase P cleavage activity with Ki of 35 μM. Framycetin competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin inhibited Hammerhead ribozyme with Ki value of 13.5 μM. Framycetin is a 5 "-Azido neomycin B precursor that binds to the Drosha site in Mir-525 and can be used for hepatic encephalopathy and enteropathogenic E. coli infection.
| Molecular Weight | 614.64 |
| Formula | C23H46N6O13 |
| CAS Number | 119-04-0 |
| Solubility (25°C) | DMSO ≥ 40 mg/mL |
| Storage | 2-8°C |
[3] W I SHEDDEN. Br Med J. FRAMYCETIN AND THE STAPHYLOCOCCUS
[4] No authors listed. S Afr Med J. Framycetin sulphate
[5] T Midtvedt. Tidsskr Nor Laegeforen. [Framycetin=Neomycin]
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