Framycetin (Neomycin B) is an aminoglycoside antibiotic, which is an effective inhibitor of RNase P cleavage activity with Ki of 35 μM. Framycetin competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin inhibited Hammerhead ribozyme with Ki value of 13.5 μM. Framycetin is a 5 "-Azido neomycin B precursor that binds to the Drosha site in Mir-525 and can be used for hepatic encephalopathy and enteropathogenic E. coli infection.
| Molecular Weight | 614.64 |
| Formula | C23H46N6O13 |
| CAS Number | 119-04-0 |
| Solubility (25°C) | DMSO ≥ 40 mg/mL |
| Storage | 2-8°C |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] W I SHEDDEN. Br Med J. FRAMYCETIN AND THE STAPHYLOCOCCUS
[4] No authors listed. S Afr Med J. Framycetin sulphate
[5] T Midtvedt. Tidsskr Nor Laegeforen. [Framycetin=Neomycin]
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