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Forsythoside H

Cat. No. M11076
Forsythoside H Structure
Size Price Availability Quantity
5mg USD 320  USD320 In stock
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Quality Control & Documentation
Biological Activity

Forsythoside H is from Forsythia suspense (Thunb.) A caffeine phenethyl alcohol glycoside (CPG) isolated from Vahl may have anti-inflammatory effects.

Chemical Information
Molecular Weight 624.59
Formula C29H36O15
CAS Number 1178974-85-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chunyan Liu, et al. J Ethnopharmacol. Synergistic anti-inflammatory effects of peimine, peiminine, and forsythoside a combination on LPS-induced acute lung injury by inhibition of the IL-17-NF-κB/MAPK pathway activation

[2] Ya-Hui Yu, et al. Zhongguo Zhong Yao Za Zhi. [Preparation and in vitro evaluation of forsythoside A-loaded exosomes]

[3] Wei Zhou, et al. Fitoterapia. Intestinal absorption of forsythoside A in different compositions of Shuang-Huang-Lian

[4] Wang-Lin Jiang, et al. Eur J Pharmacol. Neuroprotective efficacy and therapeutic window of Forsythoside B: in a rat model of cerebral ischemia and reperfusion injury

[5] Rong Shi, et al. Eur J Drug Metab Pharmacokinet. Pharmacokinetics of forsythoside after intravenous administration in beagle dogs

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