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Flavin Adenine Dinucleotide

Cat. No. M22442
Flavin Adenine Dinucleotide Structure
Size Price Availability Quantity
5mg USD 60  USD60 In stock
25mg USD 145  USD145 In stock
50mg USD 255  USD255 In stock
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Biological Activity

Flavin Adenine Dinucleotide

Chemical Information
Molecular Weight 785.55
Formula C27H33N9O15P2
CAS Number 146-14-5
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Virginia Merk, et al. Appl Spectrosc. pH-Dependent Flavin Adenine Dinucleotide and Nicotinamide Adenine Dinucleotide Ultraviolet Resonance Raman (UVRR) Spectra at Intracellular Concentration

[2] Xiaoyi Zhong, et al. Life Sci. Flavin adenine dinucleotide ameliorates hypertensive vascular remodeling via activating short chain acyl-CoA dehydrogenase

[3] Lewis M Antill, et al. J Phys Chem Lett. Flavin Adenine Dinucleotide Photochemistry Is Magnetic Field Sensitive at Physiological pH

[4] Hideaki Niwa, et al. Epigenetics. Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases

[5] M Mewies, et al. Protein Sci. Covalent attachment of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) to enzymes: the current state of affairs

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Keywords: Flavin Adenine Dinucleotide supplier, Metabolite/Endogenous Metabolite, inhibitors, activators


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