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FITC-Dextran (MW 10000)

Cat. No. M21464
FITC-Dextran (MW 10000) Structure
Size Price Availability Quantity
10mg USD 80  USD80 In stock
25mg USD 130  USD130 In stock
50mg USD 225  USD225 In stock
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Quality Control & Documentation
Biological Activity

FITC-Dextran (MW 10000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 10000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 10000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption.

Chemical Information
CAS Number 60842-46-8
Solubility (25°C) Water 50 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jizhu Li, et al. BMC Ophthalmol. Retro-orbital injection of FITC-dextran combined with isolectin B4 in assessing the retinal neovascularization defect

[2] Viki Raz Lepsky, et al. Biomolecules. FITC-Dextran Release from Cell-Embedded Fibrin Hydrogels

[3] Yangyang Xu, et al. J Neurosci Methods. Quantifying blood-brain-barrier leakage using a combination of evans blue and high molecular weight FITC-Dextran

[4] Anni Woting, et al. Nutrients. Small Intestinal Permeability and Gut-Transit Time Determined with Low and High Molecular Weight Fluorescein Isothiocyanate-Dextrans in C3H Mice

[5] Ida Eriksson, et al. Methods Mol Biol . Analysis of Lysosomal pH by Flow Cytometry Using FITC-Dextran Loaded Cells

[6] Reka Natarajan, et al. Curr Protoc Neurosci . Fluorescein Isothiocyanate (FITC)-Dextran Extravasation as a Measure of Blood-Brain Barrier Permeability

[7] Reka Natarajan, et al. Curr Protoc Neurosci. Fluorescein Isothiocyanate (FITC)-Dextran Extravasation as a Measure of Blood-Brain Barrier Permeability

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