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FHD-286

Cat. No. M11416
FHD-286  Structure
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Quality Control
  • Current batch:
  • Purity N/A
  • COA
  • MSDS
Biological Activity

FHD-286 is the first dual inhibitor of SMARCA2/SMARCA4. , can be used for metastatic melanoma and advanced hematological tumor research.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 562.66
Formula C24H30N6O6S2
CAS Number 2671128-05-3
Purity N/A
Solubility >10 μM for FaSSIF
Storage at -20°C
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