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Roblitinib(FGF-401)

Cat. No. M6095
Roblitinib(FGF-401) Structure
Synonym:

FGF401; FGF 401

Size Price Availability Quantity
5mg USD 120  USD120 In stock
10mg USD 200  USD200 In stock
50mg USD 670  USD670 In stock
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Quality Control
Biological Activity

FGF-401 is a FGFR4 inhibitor developed for the treatment of solid tumor. FGF-401 is a FGFR4 inhibitor in phase I/II clinical studies for the treatment of positive FGFR4 and KLB expresion solid tumors and hepatocellular carcinoma.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 506.56
Formula C25H30N8O4
CAS Number 1708971-55-4
Purity 99.88%
Solubility 6 mg/mL in DMSO
Storage at -20°C
References

[1] Chaiyasate K, et al. J Invest Surg. Comparing FK-506 with basic fibroblast growth factor (b-FGF) on the repair of a peripheral nerve defect using an autogenous vein bridge model.

[2] Aman A, et al. Dev Cell. Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression.

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Keywords: Roblitinib(FGF-401), FGF401; FGF 401 supplier, FGFR, inhibitors

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