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Roblitinib(FGF-401)

Cat. No. M6095
Roblitinib(FGF-401) Structure
Synonym:

FGF401; FGF 401

Size Price Availability Quantity
5mg USD 120  USD120 In stock
10mg USD 200  USD200 In stock
50mg USD 670  USD670 In stock
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Quality Control & Documentation
Biological Activity

FGF-401 is a FGFR4 inhibitor developed for the treatment of solid tumor. FGF-401 is a FGFR4 inhibitor in phase I/II clinical studies for the treatment of positive FGFR4 and KLB expresion solid tumors and hepatocellular carcinoma.

Chemical Information
Molecular Weight 506.56
Formula C25H30N8O4
CAS Number 1708971-55-4
Solubility (25°C) 6 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chaiyasate K, et al. J Invest Surg. Comparing FK-506 with basic fibroblast growth factor (b-FGF) on the repair of a peripheral nerve defect using an autogenous vein bridge model.

[2] Aman A, et al. Dev Cell. Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression.

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Keywords: Roblitinib(FGF-401), FGF401; FGF 401 supplier, FGFR, inhibitors, activators

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