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FeRhoNox-1 (Fe2+ indicator)

Cat. No. M21552
FeRhoNox-1 (Fe2+ indicator) Structure
Synonym:

RhoNox-1

Size Price Availability Quantity
50ug USD 390  USD390 In stock
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Quality Control & Documentation
Biological Activity

FeRhoNox-1, also known as RhoNox-1, is an active fluorescent probe that specifically detects unstable iron (1) ions (Fe2+). After the reaction of -denier with Fe2+, -orange (red) fluorescent products are irreversibly generated. (Absmax= 540nm, FLmax= 575nm). FeRhoNox-1 is permeable to cell membranes and highly selective, which is suitable for the detection of Fe2+ in living cells and tends to be localized in the Golgi apparatus.

Chemical Information
Solubility (25°C) N/A
Storage -20℃, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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