Farnesol is a natural sesquiterpene alcohol that is potent in treating antimetabolic disorders, anti-inflammation, showing antioxidant, anticancer, and antibiotic effects.
| Molecular Weight | 222.37 |
| Formula | C15H26O |
| CAS Number | 4602-84-0 |
| Form | Liquid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Adelaide Fernandes Costa, et al. Med Mycol. Farnesol: An approach on biofilms and nanotechnology
[5] Melanie Polke, et al. Curr Genet. Quorum sensing by farnesol revisited
| Related Metabolite/Endogenous Metabolite Products |
|---|
| 2',3'-cGAMP sodium
2',3'-cGAMP sodium is an endogenous cGAMP in mammalian cells that binds STING with high affinity and is also a potent inducer of interferon-beta (IFNβ).2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm. |
| Tryptophol
Tryptophol (Indole-3-ethanol) is an endogenous metabolite. |
| Tryptophan
DL-Tryptophan is an endogenous metabolite. |
| Tricosanoic acid
Tricosanoic acid is a long-chain fatty acid and shown to be a hair growth stimulant. |
| Tiglic acid
Tiglic acid is a monocarboxylic unsaturated organic acid found in croton oil and in several other natural products. Tiglic aci has a role as a plant metabolite. |
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