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Avexitide (Exendin 9-39)

Cat. No. M10089
Avexitide (Exendin 9-39) Structure
Synonym:

Exendin Fragment 9-39; Exendin-3 (9-39) amide

Size Price Availability Quantity
500ug USD 140  USD140 In stock
1mg USD 240  USD240 In stock
5mg USD 710  USD710 In stock
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Biological Activity

Avexitide (Exendin 9-39) is an antagonist of glucagon-like peptide-1 (GLP-1) receptor, and also acts as an inhibitor of glucosedependent insulinotropic polypeptide (GIP)-receptor binding. Avexitide (Exendin 9-39) is a competitive inhibitor of exendin-3 and exendin-4. It also prevents the production of cAMP by GIP. GLP-1, along with GIP, acts as a physiological incretin. Avexitide (Exendin 9-39) has been used to study its effect on basal microvascular permeability.

Amino Acid Sequence

Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

Chemical Information
Molecular Weight 3369.76
Formula C149H234N40O47S
CAS Number 133514-43-9
Solubility (25°C) Water 30 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kristopher C Dozier, et al. Peptides. Glucagon-like peptide-1 protects mesenteric endothelium from injury during inflammation

[2] V A Gault, et al. Diabetologia. Effects of the novel (Pro3)GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin

[3] C M Edwards, et al. Diabetes. Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: studies with the antagonist exendin 9-39

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Keywords: Avexitide (Exendin 9-39), Exendin Fragment 9-39; Exendin-3 (9-39) amide supplier, GLP Receptor, inhibitors, activators

 
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