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Avexitide (Exendin 9-39)

Cat. No. M10089

All AbMole products are for research use only, cannot be used for human consumption.

Avexitide (Exendin 9-39) Structure
Synonym:

Exendin Fragment 9-39; Exendin-3 (9-39) amide

Size Price Availability Quantity
500ug USD 140  USD140 In stock
1mg USD 240  USD240 In stock
5mg USD 710  USD710 In stock
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Biological Activity

Avexitide (Exendin 9-39) is an antagonist of glucagon-like peptide-1 (GLP-1) receptor, and also acts as an inhibitor of glucosedependent insulinotropic polypeptide (GIP)-receptor binding. Avexitide (Exendin 9-39) is a competitive inhibitor of exendin-3 and exendin-4. It also prevents the production of cAMP by GIP. GLP-1, along with GIP, acts as a physiological incretin. Avexitide (Exendin 9-39) has been used to study its effect on basal microvascular permeability.

Amino Acid Sequence

Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

Chemical Information
Molecular Weight 3369.76
Formula C149H234N40O47S
CAS Number 133514-43-9
Solubility (25°C) Water 30 mg/mL
Storage -20°C, dry, sealed
References

[1] Kristopher C Dozier, et al. Peptides. Glucagon-like peptide-1 protects mesenteric endothelium from injury during inflammation

[2] V A Gault, et al. Diabetologia. Effects of the novel (Pro3)GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin

[3] C M Edwards, et al. Diabetes. Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: studies with the antagonist exendin 9-39

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Keywords: Avexitide (Exendin 9-39), Exendin Fragment 9-39; Exendin-3 (9-39) amide supplier, GLP Receptor, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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