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Evogliptin

Cat. No. M27969

All AbMole products are for research use only, cannot be used for human consumption.

Evogliptin Structure
Synonym:

DA-1229

Price and Availability

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Quality Control & Documentation
Biological Activity

Evogliptin (DA-1229) is an orally active DPP4 inhibitor with significant and sustained hypoglycaemic effects in mouse models. Evogliptin also inhibits the production of inflammatory and fibrotic signals in hepatocytes by inducing autophagy. Evogliptin can be used in studies of type 2 diabetes, osteoporosis, renal impairment and chronic liver inflammation.

Chemical Information
Molecular Weight 401.42
Formula C19H26F3N3O3
CAS Number 1222102-29-5
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Hye-Young Seo, et al. Int J Mol Sci. Evogliptin Directly Inhibits Inflammatory and Fibrotic Signaling in Isolated Liver Cells

[2] Ping Zou, et al. Expert Rev Clin Pharmacol. Evogliptin for the treatment option for type 2 diabetes: an update of the literature

[3] Taegon Hong, et al. Br J Clin Pharmacol. Pharmacokinetics and safety of evogliptin in hepatically impaired patients

[4] Y-D Ba, et al. Eur Rev Med Pharmacol Sci. Evogliptin attenuates bleomycin-induced lung fibrosis via inhibiting TGF-β/Smad signaling in fibroblast

[5] Xueying Tan, et al. Expert Opin Pharmacother. Evogliptin: a new dipeptidyl peptidase inhibitor for the treatment of type 2 diabetes

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Keywords: Evogliptin, DA-1229 supplier, Dipeptidyl Peptidase, inhibitors, activators

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