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Evans Blue

Cat. No. M9598
Evans Blue Structure
Synonym:

Direct Blue 53; C.I. 23860

Size Price Availability Quantity
500mg USD 28  USD28 In stock
1g USD 48  USD48 In stock
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Quality Control & Documentation
Biological Activity

Evans blue is a biological dye, for detection of cell survival. Evans Blue can not penetrate healthy cell membrane, but can penetrate into death cell. Evans Blue is also a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). It is able to antagonize AMPA and kainate receptor mediated currents with IC50 values of 220 and 150 nM, respectively.

Product Citations
Chemical Information
Molecular Weight 960.81
Formula C34H24N6Na4O14S4
CAS Number 314-13-6
Solubility (25°C) Water 30 mg/mL
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Siavash Rahimi, et al. Metab Brain Dis. Neuroprotective Effects of Metformin on Traumatic Brain Injury in Rats Is Associated With the AMP-activated Protein Kinase Signaling Pathway

[2] Andrzej Wrobel, et al. Eur J Pharmacol. The Effect of O-1602, a GPR55 Agonist, on the Cyclophosphamide-Induced Rat Hemorrhagic Cystitis

[3] Isaclaudia G de Azevedo-Quintanilha, et al. Malar J. Haem Oxygenase Protects Against Thrombocytopaenia and Malaria-Associated Lung Injury

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