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Eplivanserin hemifumarate is a potent and selective 5-HT2A antagonist (IC50 values are 5.8 and 120 and >100 nM for 5-HT2A, 5-HT2B and 5-HT2C, respectively). Attenuates cocaine-induced hyperactivity. Increases dopamine (DA) release in rat medial prefrontal cortex (mPFC); potentiates haloperidol-induced DA release in the mPFC and nucleus accumbens.
| Molecular Weight | 386.42 |
| Formula | C19H21FN2O2.0.5C4H4O4 |
| CAS Number | 130580-02-8 |
| Solubility (25°C) | DMSO 19.32 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Thompson and McNiven. Nat Chem Biol. Discovery of a new 'dynasore'.
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