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EMD 281014 hydrochloride is a selective 5-HT2A antagonist; displays high affinity for human 5-HT2A over 5-HT2C receptors (Ki values are 0.87 and 557 nM respectively). Exhibits low off-target activity (Ki values are >1000 and 1268 nM for human D2 receptors and IKr channels, respectively).
| Molecular Weight | 412.89 |
| Formula | C22H21FN4O.HCl |
| CAS Number | 443144-27-2 |
| Solubility (25°C) | DMSO 41.29 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Chen, et al. Mol Pharmacol. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.
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